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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.4K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.4K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
881
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

1.0K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.0K
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

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Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
741

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Updated: Mar 30, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
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[Update: chronic inflammatory bowel disease].

Raja Atreya1, Helmut Neumann1, Markus Friedrich Neurath1

  • 1Medizinische Klinik 1 des Universitätsklinikum Erlangen.

Deutsche Medizinische Wochenschrift (1946)
|November 20, 2015
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are systemic conditions requiring individualized therapy for steroid-free remission. Treatment strategies for IBD must consider disease severity, activity, extent, and patient-specific factors for optimal outcomes.

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Area of Science:

  • Gastroenterology and immunology, focusing on inflammatory bowel diseases (IBD).
  • Systemic nature of IBD, encompassing gastrointestinal and extra-intestinal manifestations.

Context:

  • IBD, comprising Crohn's disease and ulcerative colitis, represents a significant clinical challenge.
  • Diagnosis relies on a multidisciplinary approach, integrating clinical, endoscopic, histologic, radiologic, and laboratory data.
  • IBD's systemic impact necessitates comprehensive management beyond the gastrointestinal tract.

Purpose:

  • To outline the principles of rational medical therapy for IBD.
  • To emphasize the goal of achieving and maintaining steroid-free remission.
  • To highlight the critical need for personalized therapeutic strategies in IBD management.

Summary:

  • IBD are diagnosed clinically, supported by various diagnostic modalities.
  • Medical therapy aims for steroid-free remission, tailored to disease characteristics (severity, activity, extent) and patient's disease course.
  • Individualized treatment is essential due to the variable natural history of IBD.

Impact:

  • Informed clinical decision-making for IBD treatment selection.
  • Improved patient outcomes through targeted, individualized therapeutic approaches.
  • Enhanced understanding of IBD as a systemic disease requiring holistic management.