Related Experiment Video
Updated: Mar 30, 2026
Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
Published on: July 15, 2019
A UNIQUE POSTERIOR SEGMENT PHENOTYPIC MANIFESTATION OF COXSACKIE VIRUS INFECTION
Chandrakumar Balaratnasingam1, David R Lally, Kirstin L Tawse
1*Vitreous-Retina-Macula Consultants of New York, New York, New York; †The LuEsther T. Mertz Retinal Research Center, New York, New York; ‡Department of Physiology and Pharmacology, Centre for Ophthalmology and Visual Sciences, Lions Eye Institute, University of Western Australia, Perth, Australia; §Department of Ophthalmology, New England Eye Center, Tufts Medical Center, Boston, Massachusetts; ¶New York Eye and Ear Institute, New York, New York; **Good Samaritan Hospital, Suffern, New York, New York; ††Rockland Retina, New City, New York; ‡‡Department of Ophthalmology, New York University School of Medicine, New York, New York; and §§Manhattan Eye, Ear and Throat Hospital/Northshore Long Island Jewish Hospital, New York, New York.
Purpose:
To report a posterior segment phenotypic manifestation of Coxsackie virus infection that has not been previously appreciated.
Methods:
The clinical course and multimodal imaging findings, including spectral domain optical coherence tomography, fluorescein angiography, near infrared reflectance, and fundus autofluorescence of two patients with Coxsackie virus infections were documented.
Results:
A neurosensory macular detachment was present in both patients on baseline examination. Fluorescein angiography demonstrated pooling within this lesion and spectral domain optical coherence tomography identified thickening of the retinal pigment epithelial band with variable degrees of attenuation of the ellipsoid zone and interdigitation zone. Fundus autofluorescence and near infrared reflectance imaging revealed multiple satellite lesions adjacent to the neurosensory detachment. These lesions were not seen on fluorescein angiography or color photography. Satellite lesions were hyporeflective on near infrared reflectance imaging and hyperautofluorescent on fundus autofluorescence imaging. The satellite lesions correlated with sites of ellipsoid disruption on spectral domain optical coherence tomography. Both patients were observed and their condition improved over the course of time. There was total resolution of satellite lesions, reconstitution of the ellipsoid zone and interdigitation zone, and return of retinal pigment epithelial thickness to the normal range. A bull's eye pattern of macular retinal pigment epithelial disturbance persisted on color and near infrared reflectance images, despite good visual acuity.
Conclusion:
Posterior segment Coxsackie virus infection may concurrently express the clinical characteristics of acute idiopathic maculopathy and multifocal retinitis. The visual prognosis in this variant is usually favorable. The multimodal imaging features that characterize this entity should be recognized to avoid confusion with other diseases that have a similar presentation.
More Related Videos
Related Concept Videos
01:25Endocarditis II: Clinical Features of Infective Endocarditis
01:27Cytomegalovirus Disease
01:18Viral Meningitis
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
01:30Acute Pharyngitis
Acute pharyngitis is the inflammation of the back of the throat (pharynx), commonly resulting in a sore throat. It is a frequently encountered condition that prompts individuals to seek medical advice.
Classification
Acute pharyngitis can be categorized based on its underlying cause:
01:25Arboviral Encephalitis