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Gastrinoma in a mesenteric lymph node.

M Kitagawa1, T Hayakawa, T Kondo

  • 1Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.

The American Journal of Gastroenterology
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

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A patient with Zollinger-Ellison syndrome had a gastrinoma, a rare tumor, successfully removed from the duodenum. This surgical intervention normalized gastrin levels and resolved symptoms, highlighting effective tumor localization and resection.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Surgical Oncology

Background:

  • Zollinger-Ellison syndrome is characterized by elevated gastrin levels leading to peptic ulcers.
  • Diagnosis can be challenging due to the difficulty in locating the gastrinoma, often a neuroendocrine tumor.

Observation:

  • A 36-year-old male presented with severe vomiting and diarrhea, indicative of Zollinger-Ellison syndrome.
  • Initial diagnostic imaging failed to pinpoint the tumor, despite high serum gastrin and a positive secretin provocative test.

Findings:

  • Advanced imaging techniques, including CT scan and selective angiography, successfully localized a 2-cm duodenal mesenteric tumor.
  • Histopathological analysis confirmed the tumor as an islet cell tumor, expressing gastrin exclusively via immunohistochemistry.

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Implications:

  • Surgical excision of the gastrinoma led to normalization of serum gastrin and resolution of symptoms.
  • This case underscores the importance of persistent diagnostic efforts and advanced imaging in managing Zollinger-Ellison syndrome.