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Thrombophilia testing in young patients with ischemic stroke
Sidse Høst Pahus1, Anette Tarp Hansen1, Anne-Mette Hvas1
1Center for Hemophilia and Thrombosis, Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.
Thrombosis Research
|November 21, 2015
Summary
Thrombophilia does not increase ischemic stroke risk in young adults. However, Factor V Leiden heterozygotes face higher TIA/amaurosis fugax risk, and lupus anticoagulant may link to stroke.
Area of Science:
- Neurology
- Hematology
- Vascular Medicine
Background:
- The role of thrombophilia in young ischemic stroke patients is debated.
- Investigating inherited and acquired thrombophilias as risk factors for cerebrovascular events in young individuals.
Purpose of the Study:
- To assess the association between thrombophilia and ischemic stroke, transient ischemic attack (TIA), and amaurosis fugax in patients aged 18-50.
- To determine if specific thrombophilias confer increased risk for these conditions.
Main Methods:
- Retrospective study of 685 patients (18-50 years) undergoing thrombophilia testing.
- Data collected from Danish Stroke Registry, medical records, and laboratory systems.
- Analysis of thrombophilia prevalence and odds ratios (OR) for ischemic stroke and TIA/amaurosis fugax.
Main Results:
- No strong association between thrombophilia and ischemic stroke was found.
- Factor V Leiden heterozygosity (12%) showed a significantly higher risk for TIA/amaurosis fugax (OR: 1.99).
- Persistent lupus anticoagulant (3%) was possibly associated with ischemic stroke (OR: 2.66).
Conclusions:
- Thrombophilia is not a significant risk factor for ischemic stroke in young patients.
- Factor V Leiden heterozygosity increases TIA/amaurosis fugax risk; persistent lupus anticoagulant may be linked to ischemic stroke.
- Recommend thrombophilia testing be restricted to persistent lupus anticoagulant investigation in this demographic.
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