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Published on: October 23, 2018
Cardiac GR and MR: From Development to Pathology.
Rachel V Richardson1, Emma J Batchen2, Martin A Denvir2
1Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK; Current address: Institute of Genetic Medicine, Newcastle University, International Centre for Life, Central Parkway, Newcastle Upon Tyne, NE1 3BZ, UK.
Mineralocorticoid receptor (MR) antagonism treats heart failure. Glucocorticoid (GC) receptor (GR) also plays a key role in preventing heart disease, influencing cardiac health and disease.
Area of Science:
- Cardiology
- Endocrinology
- Molecular Biology
Background:
- Mineralocorticoid receptor (MR) antagonism is effective for heart failure, underscoring aldosterone's role.
- Cardiac glucocorticoid receptor (GR) function in heart disease is increasingly recognized.
- GR and MR share structural and functional homology but differ in cellular outcomes.
Purpose of the Study:
- To review evidence for the role of cardiac GR in preventing heart disease.
- To explore the implications of GR and MR balance in cardiac development and pathology.
Main Methods:
- Review of recent animal model evidence.
- Analysis of the interplay between GR and MR signaling pathways.
Main Results:
- Animal models reveal a protective role for glucocorticoid (GC) signaling via GR in cardiomyocytes.
- Evidence suggests a tonic action of GC via GR in preventing heart disease.
Conclusions:
- A balance between GR and MR activation is crucial for early heart maturation.
- This balance impacts long-term cardiac health and susceptibility to disease.
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