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Related Experiment Videos

Indomethacin-induced oligohydramnios.

R L Goldenberg1, R O Davis, R C Baker

  • 1Department of Obstetrics and Gynecology, University of Alabama, Birmingham 35294.

American Journal of Obstetrics and Gynecology
|May 1, 1989
PubMed
Summary

Indomethacin can cause reversible oligohydramnios (low amniotic fluid) in pregnant individuals. Higher doses of indomethacin may lead to a greater reduction in amniotic fluid levels.

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Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Fetal Medicine

Background:

  • Oligohydramnios, a condition characterized by low amniotic fluid, can lead to adverse fetal outcomes.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, are sometimes used in pregnancy for specific indications.
  • The potential effects of NSAIDs on fetal renal function and amniotic fluid production require careful consideration.

Observation:

  • A case report details a pregnant individual who developed oligohydramnios during indomethacin therapy.
  • The oligohydramnios resolved after discontinuation of indomethacin treatment, indicating a reversible effect.
  • The severity of the oligohydramnios appeared to correlate with the dosage of indomethacin administered.

Findings:

  • This case suggests a direct relationship between indomethacin dosage and the degree of amniotic fluid reduction.
  • Indomethacin-induced oligohydramnios is a potentially reversible condition.
  • Fetal renal perfusion and urine output may be affected by indomethacin, impacting amniotic fluid volume.

Implications:

  • Clinicians should be aware of the risk of indomethacin-induced oligohydramnios when prescribing this medication during pregnancy.
  • Careful monitoring of amniotic fluid levels is recommended for pregnant individuals receiving indomethacin.
  • Dosage adjustments or alternative medications may be considered to mitigate this risk.

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