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Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
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Injury-Mediated Vascular Regeneration Requires Endothelial ER71/ETV2

Changwon Park1, Tae-Jin Lee1, Suk Ho Bhang1

  • 1Department of Pediatrics (C.P., H.S.C.), Children's Heart Research and Outcomes Center (C.P.), Molecular and Systems Pharmacology Program (C.P.), Emory University School of Medicine, Atlanta; Department of Pharmacology, College of Medicine, University of Illinois at Chicago, IL (T.M.K., N.U., M.U-F.); School of Chemical Engineering, Sungkyunkwan University, Korea (S.H.B.); School of Chemical and Biological Engineering, Seoul National University, Seoul, Korea (B-S.K.); Korea Advanced Institute of Science and Technology, Korea (D.J.L., D-S.L.); RIKEN BioResource Center, Japan (H.M.); the Departments of Pathology and Immunology (T-J.L., F.L., K.C.), Ophthalmology and Visual Sciences (R.N., I.P-R., R.S.A.), Developmental Biology (S.S.O., D.M.O.), Biochemistry and Molecular Biophysics (B. C.), Developmental, Regenerative, and Stem cell Biology Program (D.M.O., R.S.A., K.C.), Washington University School of Medicine, MO.

Arteriosclerosis, Thrombosis, and Vascular Biology
|November 21, 2015
PubMed
Summary

The transcription factor Ets variant 2 (ETV2) is crucial for adult vascular regeneration and repair. Its absence impairs neovascularization, while its expression promotes blood vessel formation and recovery from ischemic injury.

Keywords:
endothelial cellshematopoietic systemshindlimb ischemiaregeneration

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