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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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Retargeted oncolytic viruses provoke tumor-directed T-cell responses

Arnold Kloos1, Norman Woller2, Rita Gerardy-Schahn3

  • 1Clinic of Gastroenterology; Hepatology and Endocrinology; Hannover Medical School ; Hannover, Germany ; Department of Hematology; Hemostasis; Oncology and Stem Cell Transplantation; Hannover Medical School ; Hannover, Germany.

Oncoimmunology
|November 21, 2015
PubMed

Insights

Systemic application of oncolytic viruses can be enhanced for cancer immunotherapy. Molecular retargeting of viral infection overcomes limitations, improving tumor-directed immune responses for effective antitumor immunity.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Intratumoral administration of oncolytic viruses effectively stimulates tumor-directed immune responses.
  • Systemic application of oncolytic viruses is limited in eliciting sufficient tumor inflammation for antitumor immunity.

Purpose of the Study:

  • To investigate methods for overcoming the limitations of systemic oncolytic virus application.
  • To explore the potential of molecular retargeting to enhance viral infection and antitumor immunity.

Main Methods:

  • Investigated molecular retargeting strategies for viral infection.
  • Assessed the impact of retargeting on tumor inflammation and immune responses.

Main Results:

  • Evidence suggests molecular retargeting can overcome barriers to systemic oncolytic virus efficacy.
  • Retargeting enhances viral infection and subsequent antitumor immune responses.

Conclusions:

  • Molecular retargeting represents a promising strategy to improve systemic oncolytic virotherapy.
  • Enhanced viral targeting can lead to more effective antitumor immunity.
Keywords:
oncolytic virus, molecular retargeting, neoepitope-specific T cell responses

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