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ISG15: A double edged sword in cancer
1Department of Biochemistry & Molecular Biology; LSU Health Sciences Center-School of Medicine ; New Orleans, LA USA.
Abstract:
Interferon-Stimulated Gene 15 (ISG15) transcript is aberrantly expressed in most human malignancies, suggesting that it has a protumor function. However, at the protein level ISG15 has both protumor and immunomodulatory antitumor functions. Therapeutic strategies to maximize the latter may benefit cancer patients overexpressing the ISG15 pathway.
Insights
Interferon-Stimulated Gene 15 (ISG15) shows dual roles in cancer. While its transcript suggests a tumor-promoting function, ISG15 protein offers both tumor promotion and anti-cancer immune effects.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Aberrant expression of Interferon-Stimulated Gene 15 (ISG15) transcript is common in human cancers.
- ISG15's role in malignancy is complex, with transcript suggesting protumor functions.
- ISG15 protein exhibits both protumor and immunomodulatory antitumor functions.
Purpose of the Study:
- To investigate the dual role of ISG15 in human malignancies.
- To explore therapeutic strategies targeting the ISG15 pathway for cancer treatment.
Main Methods:
- Analysis of ISG15 expression at transcript and protein levels in various cancers.
- Evaluation of ISG15's protumor and antitumor functions.
Main Results:
- ISG15 transcript overexpression correlates with malignancy, suggesting a protumor role.
- ISG15 protein demonstrates a dual function, possessing both protumor and immunomodulatory antitumor activities.
- The immunomodulatory antitumor functions of ISG15 present therapeutic potential.
Conclusions:
- Understanding the dual role of ISG15 is crucial for cancer therapy.
- Therapeutic strategies aimed at enhancing ISG15's immunomodulatory antitumor functions could benefit cancer patients, particularly those with high ISG15 pathway expression.
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