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Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D
Elizabeth E Evans1, Mark Paris1, Ernest S Smith1
1Vaccinex, Inc. ; Rochester, NY USA.
Abstract:
Semaphorin 4D is highly expressed at the invasive tumor margin and acts as a guidance molecule, restricting movement of tumoricidal immune cells into the tumor microenvironment. We recently showed that antibody neutralization of SEMA4D augmented activated monocyte and anticancer T-cell tumor penetration and that anti-SEMA4D antibody potentiated other immunomodulatory therapies in murine tumor models.
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