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Updated: Mar 30, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
Published on: July 25, 2020
Targeting STING pathways for the treatment of cancer
Claudia Gravekamp1, Dinesh Chandra1
1Albert Einstein College of Medicine; Department of Microbiology and Immunology ; New York, NY USA.
Abstract:
Recently, we demonstrated that stimulator of interferon genes (STING) ligand cyclic di-guanylate (c-di-GMP) is an excellent adjuvant in cancer vaccination but also induces immunogenic tumor cell death. Combination of both pathways resulted in a nearly complete elimination of the metastases in a breast cancer model. This study is discussed below.
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