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Heparin-induced thrombocytopenia
1Department of Medicine, McMaster University Medical Centre, Ontario, Canada.
Heparin-induced thrombocytopenia is the most important idiosyncratic drug-induced thrombocytopenia because of its high frequency and association with arterial thrombosis. Recent evidence implicates heparin-IgG immune complexes in the pathogenesis of this disorder. New developments such as a diagnostic test for heparin-induced thrombocytopenia and current treatment recommendations are reviewed.
Heparin-induced thrombocytopenia is the most important idiosyncratic drug-induced thrombocytopenia because of its high frequency and association with arterial thrombosis. Recent evidence implicates heparin-IgG immune complexes in the pathogenesis of this disorder. New developments such as a diagnostic test for heparin-induced thrombocytopenia and current treatment recommendations are reviewed.
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