Related Experiment Video
Updated: Jun 27, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis
1Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02130.
Abstract:
Chronic obstructive pulmonary disease (COPD) is defined in this chapter, and the relation between its two major components, (a) chronic bronchitis and emphysema and (b) nonremitting asthma, is discussed. Intensity of tobacco smoking and age are the major risk factors for the development of chronic airways obstruction. Environmental air pollution, childhood infections, and familial factors other than alpha-1 protease inhibitor deficiency appear to play only small roles. Emphysema is the major cause of severe airways obstruction; bronchiolitis is a contributing factor and likely is responsible for the minor reversible element of airways obstruction. The elastase-antielastase hypothesis, which is based mainly on indirect evidence, is the best explanation for the pathogenesis of emphysema. Extensive airspace enlargement with fibrosis is infrequently observed; this mechanism may play a role in the pathogenesis of the centrilobular emphysema of smokers.
More Related Videos
05:34Auricular Acupuncture as a Traditional Chinese Medicine Therapy for Chronic Obstructive Pulmonary Disease Combined with Sleep Disorders
Published on: August 18, 2023
04:03Alternative Therapy for Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Moving Cupping Along Meridians
Published on: September 27, 2024
Related Concept Videos
COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Chronic Obstructive Pulmonary Disease I: Introduction
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features