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Related Experiment Video

Updated: Mar 30, 2026

Assessment of Static Graviceptive Perception in the Roll-Plane using the Subjective Visual Vertical Paradigm
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Interventions for dissociated vertical deviation.

Sarah R Hatt1, Xue Wang, Jonathan M Holmes

  • 1Department of Ophthalmology, Mayo Clinic, Guggenheim 9, 200 1st St. SW, Rochester, Minnesota, USA, 55905.

The Cochrane Database of Systematic Reviews
|November 21, 2015
PubMed
Summary
This summary is machine-generated.

This review found limited evidence on treatments for dissociated vertical deviation (DVD), a type of eye misalignment. More high-quality randomized controlled trials are needed to determine the most effective interventions for DVD.

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Area of Science:

  • Ophthalmology
  • Strabismus Management
  • Clinical Trials

Background:

  • Dissociated vertical deviation (DVD) is an upward eye misalignment that can be manifest or controlled.
  • DVD often co-occurs with horizontal strabismus and can cause psychosocial concerns or eyestrain.
  • Surgical intervention is the standard treatment for DVD, but non-surgical options are less common.

Purpose of the Study:

  • To evaluate the effectiveness and safety of surgical and non-surgical interventions for DVD.
  • To synthesize findings from randomized controlled trials (RCTs) on DVD treatments.

Main Methods:

  • Comprehensive literature search across multiple databases (CENTRAL, MEDLINE, EMBASE, PubMed, LILACS, mRCT, ClinicalTrials.gov, ICTRP).
  • Inclusion of randomized controlled trials (RCTs) assessing interventions for DVD.
  • Independent data extraction and risk of bias assessment by two review authors.

Main Results:

  • Four RCTs involving 151 participants (6 months to 22 years) were included, all with unclear risk of bias.
  • Limited data were available for primary outcome analysis; one trial showed uncertain differences between two surgical techniques for DVD.
  • Adverse events were generally low, including hypotropia and need for repeat surgery.

Conclusions:

  • The included RCTs assessed five surgical procedures for DVD but suffered from methodological limitations.
  • Insufficient reporting of study methods and data prevent firm conclusions on treatment effectiveness.
  • High-quality RCTs are urgently needed to establish optimal management strategies for DVD.