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Overview of Cell Death

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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...

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Related Experiment Video

Updated: Mar 29, 2026

Detection and Isolation of Apoptotic Bodies to High Purity

Detection and Isolation of Apoptotic Bodies to High Purity

Published on: August 12, 2018

Apoptosis Evaluation by Electrochemical Techniques.

Jian Yin¹, Peng Miao^2,3

¹CAS Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, 215163, P.R. China.

Chemistry, an Asian Journal

|November 21, 2015

Summary

This summary is machine-generated.

Electrochemical biosensors offer a sensitive, low-cost method for detecting apoptosis, crucial for understanding cell death in biology, medicine, and drug development.

Keywords:

apoptosis biosensors electrochemistry enzymes peptides

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Cell Biology

Background:

Apoptosis, or programmed cell death, is integral to pathology, pharmacology, and toxicology.
Accurate detection of apoptosis aids biological study, clinical diagnosis, and drug development.
Various analytical techniques exist for apoptosis detection, including SPR, electrochemistry, flow cytometry, and imaging.

Purpose of the Study:

To provide an overview of technical approaches for apoptosis evaluation.
To summarize recently developed electrochemical biosensors for apoptotic cell detection.
To highlight the advantages of electrochemical biosensors over traditional methods.

Main Methods:

Review of existing literature on apoptosis detection techniques.
Focus on electrochemical biosensors and their underlying principles.
Analysis of recognition element design based on apoptotic biochemical events.

Main Results:

Electrochemical techniques offer simplicity, ease of operation, low cost, and high sensitivity for in vitro biological systems.
Electrochemical biosensors present advantages over traditional methods for detecting apoptotic cells.
Designing recognition elements based on biochemical events during apoptosis is a key consideration.

Conclusions:

Electrochemical biosensors are powerful tools for sensitive apoptosis detection.
These biosensors facilitate biological research, clinical diagnostics, and pharmaceutical development.
Further development focuses on optimizing recognition elements for enhanced apoptosis evaluation.