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Author Spotlight: Optimizing EAS with Long Electrodes for Enhanced Cochlear Coverage and Hearing Preservation
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Cochlear sensitivity in children with chronic kidney disease and end-stage renal disease undergoing hemodialysis

Rahime Renda1, Levent Renda2, Ömer Tarık Selçuk2

  • 1Department of Pediatric Nephrology, Antalya Research and Education Hospital, Antalya, Turkey.

International Journal of Pediatric Otorhinolaryngology
|November 22, 2015
PubMed

Insights

Children with chronic kidney disease (CKD) show impaired cochlear function, even with normal hearing. Longer hemodialysis (HD) duration is linked to hearing loss, highlighting the need for monitoring CKD patients.

Area of Science:

  • Nephrology
  • Audiology
  • Pediatrics

Background:

  • Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are associated with auditory system abnormalities.
  • Hemodialysis (HD) is a common treatment for ESRD, but its impact on hearing is not fully understood.

Purpose of the Study:

  • To investigate the relationship between cochlear sensitivity and hemodialysis in pediatric patients with CKD.
  • To compare hearing function in non-dialytic CKD patients, dialytic ESRD patients, and healthy controls.

Main Methods:

  • The study included 3 groups: non-dialytic CKD patients (36), dialytic ESRD patients (16), and healthy controls (30), aged 6-18 years.
  • Hearing health was assessed using tympanometry, pure-tone audiometry, and distortion product otoacoustic emissions (DPOAEs).
  • Biochemical markers (blood urea nitrogen, serum cystatin C) and disease duration were analyzed.

Main Results:

  • DPOAE amplitudes and signal-to-noise ratios were significantly lower in both non-dialytic and dialytic CKD groups compared to controls.
  • Even patients with normal hearing thresholds exhibited reduced DPOAEs compared to healthy children.
  • The duration of CKD, cystatin C, and blood urea levels were not associated with hearing loss, but HD duration showed a significant association.

Conclusions:

  • Cochlear function is impaired in pediatric patients with CKD, irrespective of their hearing thresholds.
  • Regular monitoring of hearing function is recommended for all CKD patients, including those on dialysis, to prevent further auditory deterioration.
  • Avoiding potential ototoxic agents is crucial for managing hearing health in this population.
Abstract

Keywords:
Chronic kidney diseaseHearing lossHemodialysisOtoacoustic emissions

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