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Potent Antibody Protection against an Emerging Alphavirus Threat
Margaret Kielian1, Erica Ollmann Saphire2
1Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cell
|November 23, 2015
Abstract:
Chikungunya virus recently caused large outbreaks world-wide. In this issue of Cell, Fox et al. describe several potently neutralizing antibodies against multiple alphaviruses. The structure of the virus in complex with one of the antibodies reveals the antibody-induced rearrangement and crosslinking of the viral surface proteins that result in neutralization.
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