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Enhancing Vaccine Safety Capacity Globally: A Lifecycle Perspective
Robert T Chen1, Tom T Shimabukuro1, David B Martin2
1Office of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States.
American Journal of Preventive Medicine
|November 23, 2015
Summary
Vaccine safety controversies are ongoing due to maturing immunization programs. This paper explores lifecycle strategies to enhance vaccine safety capacity globally.
Area of Science:
- Immunology
- Public Health
- Pharmacovigilance
Background:
- Vaccine safety controversies have emerged globally since the late 20th century.
- Maturing national immunization programs highlight adverse events following immunization (AEFI), including true reactions and coincidental events.
- These controversies are expected to persist as vaccine-preventable diseases decline.
Purpose of the Study:
- To examine pre- and post-licensure opportunities for improving vaccine safety.
- To adopt a comprehensive "lifecycle" approach to vaccine safety.
- To address vaccine safety in both developed (U.S., Europe) and low- and middle-income countries.
Main Methods:
- Lifecycle approach to vaccine safety assessment.
- Review of pre-licensure vaccine safety evaluation.
- Analysis of post-licensure vaccine safety monitoring and capacity building.
Main Results:
- Identified key opportunities for enhancing vaccine safety throughout the product lifecycle.
- Highlighted the need for robust safety monitoring systems.
- Emphasized the importance of tailored strategies for different economic contexts.
Conclusions:
- Proactive and comprehensive strategies are crucial for mitigating vaccine safety controversies.
- Improving vaccine safety capacity requires a lifecycle perspective.
- Global collaboration is essential for ensuring vaccine safety worldwide.
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