[USING MEXICOR TO CORRECT THE FUNCTIONAL PARAMETERS OF RED BLOOD CELLS IN RATS WITH TRAUMATIC BRAIN INJURY MODEL]

Area of Science:

• Biomedical science
• Neuroscience
• Hematology

Context:

• Traumatic brain injury (TBI) significantly impairs erythrocyte function, increasing aggregation and malonic dialdehyde (MDA) levels while decreasing electrophoretic mobility.
• The post-traumatic period is characterized by oxidative stress and altered red blood cell (RBC) parameters.

Purpose:

• To investigate the therapeutic effects of mexicor on erythrocyte functional characteristics in a rat model of TBI.
• To evaluate the impact of mexicor on RBC aggregation, MDA concentration, electrophoretic mobility, and 2,3-diphosphoglycerate levels post-TBI.

Summary:

• TBI in rats induced a 143% increase in erythrocyte aggregation, a 40% rise in MDA, and a 22% decrease in electrophoretic mobility.
• Mexicor administration (8.0 mg/day for 12 days) significantly counteracted these effects, reducing MDA by 61% and aggregation by 36%, while increasing electrophoretic mobility by 20% within 3-7 days.
• Mexicor also increased 2,3-diphosphoglycerate concentrations by 23% on day 7 and shortened RBC functional parameter recovery by 40% compared to controls.

Impact:

• Mexicor demonstrates significant efficacy in mitigating TBI-induced erythrocyte dysfunction.
• The findings suggest mexicor's potential as a therapeutic agent for managing complications associated with traumatic brain injury.
• This study highlights the role of mexicor in restoring red blood cell health and accelerating recovery following TBI.