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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
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[Melatonin as a universal modulator of any pathological processes ].

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[Role of renin-angiotensin system in cardiovascular effects of melatonin].

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[MELATONIN TREATMENT OF AUTOIMMUNE AND ALLERGIC PATHOLOGY].

E B Arushanian

    Eksperimental'Naia I Klinicheskaia Farmakologiia
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    Summary
    This summary is machine-generated.

    Melatonin hormone production is disrupted in autoimmune and allergic diseases. Supplementing with melatonin shows protective effects, suggesting its potential for treating these conditions.

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    Area of Science:

    • Immunology
    • Endocrinology
    • Neuroscience

    Context:

    • Autoimmune and allergic diseases, including systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, and atopic dermatitis, are linked to disrupted melatonin production.
    • Melatonin, a hormone produced by the pineal gland and peripheral tissues, plays a role in immune system regulation.

    Purpose:

    • To investigate the role of melatonin in autoimmune and allergic diseases.
    • To evaluate the therapeutic potential of melatonin administration in managing these conditions.

    Summary:

    • Disturbances in natural melatonin production are observed in patients with various autoimmune and allergic diseases.
    • Preclinical and clinical studies indicate a protective effect of exogenous melatonin administration in these pathologies.
    • Further research is warranted to explore melatonin's efficacy for clinical application in autoimmune disorder treatment.

    Impact:

    • Melatonin supplementation may offer a novel therapeutic strategy for autoimmune and allergic diseases.
    • Understanding melatonin's immunomodulatory functions could lead to improved treatment protocols.
    • This research could pave the way for integrating melatonin into standard clinical practice for managing immune-related disorders.