Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kawasaki syndrome.

J W Newburger1, J C Burns

  • 1Department of Pediatrics, Harvard Medical School, Boston, Massachusetts.

Cardiology Clinics
|May 1, 1989
PubMed
Summary
This summary is machine-generated.

Kawasaki syndrome can cause pediatric heart disease, but early treatment with intravenous gamma globulin significantly reduces coronary artery aneurysm risk. Long-term monitoring is crucial for all patients to track heart and valve health.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tricuspid Regurgitation and Impact of Surgical Valve Intervention in the Single Ventricle Reconstruction Trial.

Pediatric cardiology·2026
Same author

Kawasaki disease for the paediatric dermatologist: skin manifestations and new insights into the pathophysiology.

Clinical and experimental dermatology·2021
Same author

Characterization of circulating immune cells in acute Kawasaki disease suggests exposure to different antigens.

Clinical and experimental immunology·2020
Same author

Association of Isolated Congenital Heart Disease with Fetal Brain Maturation.

AJNR. American journal of neuroradiology·2020
Same author

Cardiovascular imaging in children and adults following Kawasaki disease.

Insights into imaging·2015
Same author

2015 SPCTPD/ACC/AAP/AHA Training Guidelines for Pediatric Cardiology Fellowship Programs (Revision of the 2005 Training Guidelines for Pediatric Cardiology Fellowship Programs).

Journal of the American College of Cardiology·2015
Same journal

At the Edge of the Possible: A New Standard for Cardiovascular Critical Care.

Cardiology clinics·2026
Same journal

End-of-Life Care in the Cardiovascular Intensive Care Unit.

Cardiology clinics·2026
Same journal

Strategies to Reduce Failure to Rescue after Cardiac Surgery.

Cardiology clinics·2026
Same journal

Embracing Enhanced Recovery After Cardiac Surgery Program.

Cardiology clinics·2026
Same journal

Post-Heart Transplantation Intensive Care Unit Recovery: A Phase-Based Approach.

Cardiology clinics·2026
Same journal

A Practical Guide to Intensive Care Unit Management after Left Ventricular Assist Device Implantation.

Cardiology clinics·2026
See all related articles

Area of Science:

  • Pediatric Cardiology
  • Immunology
  • Vascular Biology

Background:

  • Kawasaki syndrome is a primary cause of acquired pediatric heart disease in the US.
  • Coronary artery aneurysms affect 15-25% of children with Kawasaki syndrome.
  • Intravenous gamma globulin (IVIG) treatment in acute Kawasaki syndrome reduces aneurysm risk 3-5 fold.

Purpose of the Study:

  • To review the long-term sequelae of Kawasaki syndrome.
  • To assess the impact on coronary artery status, myocardial function, and valvar regurgitation.
  • To highlight the need for continued surveillance in affected children.

Main Methods:

  • Review of existing literature on Kawasaki syndrome outcomes.
  • Analysis of angiographic, histologic, and functional data.

Related Experiment Videos

  • Evaluation of myocardial and valvar function in patients with and without coronary artery disease.

    • Main Results:

    • Half of aneurysmal coronary segments resolve angiographically but retain histologic/functional deficits.
    • Remaining aneurysms may progress to stenosis or occlusion.
    • Myocarditis is universal in acute Kawasaki syndrome; late myocardial dysfunction is debated, especially without coronary artery disease.
    • Aortic and mitral regurgitation can occur acutely, with rare late-onset complications.

    Conclusions:

    • Long-term surveillance is essential for Kawasaki syndrome patients.
    • Monitoring should encompass coronary artery status, myocardial function, and valvar regurgitation.
    • Understanding the natural history informs management and predicts long-term outcomes.