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Updated: Mar 29, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
Published on: May 31, 2016
Cross-talk between bone morphogenetic proteins and inflammatory pathways
Peter M van der Kraan1, Esmeralda N Blaney Davidson2
1Experimental Rheumatology, Department of Rheumatology, Radboudumc, Geert Grooteplein 26, 6525 GA, Nijmegen, The Netherlands. Peter.vanderkraan@radboudumc.nl.
Abstract:
Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and developmental biology. Varas and colleagues report that these factors show cross-talk in rheumatoid arthritis synoviocytes. They show that pro-inflammatory cytokines not only stimulate the production of bone morphogenetic proteins but that these endogenously produced bone morphogenetic proteins interfere with the effects of pro-inflammatory cytokines on synoviocytes.
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