Related Experiment Video
Updated: Mar 29, 2026
05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
2.2K
Recent progress in continuous and semi-continuous processing of solid oral dosage forms: a review
Michał Teżyk1,2, Bartłomiej Milanowski2, Andrzej Ernst1
1a Gedeon Richter Polska Sp. z o.o. , Grodzisk Mazowiecki , Poland ;
Drug Development and Industrial Pharmacy
|November 24, 2015
Summary
The pharmaceutical industry is transitioning to continuous manufacturing for solid oral dosage forms. This shift requires a change in mindset to fully realize the benefits of continuous processing over traditional batch methods.
Area of Science:
- Pharmaceutical Manufacturing
- Chemical Engineering
- Process Technology
Background:
- The pharmaceutical industry is exploring innovative production concepts like continuous manufacturing.
- Traditional batch-wise production is being challenged by modern continuous manufacturing models.
Purpose of the Study:
- To present technological advancements in continuous and semi-continuous processing for solid oral dosage forms.
- To review sophisticated integrated continuous manufacturing systems.
Main Methods:
- Review of single unit processes adaptable to continuous manufacturing.
- Discussion of semi-continuous processing concepts.
- Analysis of integrated production systems from powder to final dosage form.
- Description of end-to-end production approaches linking API synthesis with dosage form manufacturing.
Main Results:
- Growing scientific interest in continuous processing for pharmaceuticals.
- Development of integrated continuous manufacturing lines ('powder to tablet').
- Research focuses on process parameter influence, process analytical technology, control systems, and computational methods.
- Successful integration of primary and secondary production steps in continuous lines.
Conclusions:
- A shift in mindset is crucial for evaluating the advantages and disadvantages of continuous manufacturing.
- Adoption of continuous processing requires a comprehensive understanding of its implications.
More Related Videos
Related Concept Videos
01:26Oral Drug Delivery Systems: Continuous-Release Systems
212
Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
212
01:23Oral Drug Delivery Systems: Introduction
209
Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
209
01:18Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
403
Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
403
01:11Oral Drug Delivery Systems: Delayed-Release Systems
144
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
144
01:27Drug Delivery Systems: Different Types
240
Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
240
01:18Routes of Drug Administration: Enteral
8.3K
Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...
8.3K