Related Experiment Video
Updated: Sep 28, 2025
05:44
Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
1.7K
Dispensing of minitablets - Has the problem been resolved?
Arkadiusz Hejduk1, Janina Lulek2
1Chair and Department of Pharmaceutical Technology, Faculty of Pharmacy, Poznan University of Medical Sciences, 6 Grunwaldzka Street, 60-780 Poznan, Poland; Przedsiębiorstwo Farmaceutyczne LEK-AM Sp. z o.o., 14A Ostrzykowizna Street, 05-170 Zakroczym, Poland.
International Journal of Pharmaceutics
|March 27, 2022
Summary
Minitablets offer personalized therapy, especially for patients with swallowing difficulties. However, current packaging and dispensing systems need improvement for safe and convenient administration, particularly for small-diameter minitablets.
Area of Science:
- Pharmaceutical technology
- Drug delivery systems
Background:
- Minitablets align with personalized medicine trends, offering advantages for patients with swallowing difficulties.
- Existing packaging and dispensing methods for minitablets are often inadequate for safe and convenient drug administration.
Purpose of the Study:
- To critically review and discuss current dosing options for minitablets.
- To identify limitations and areas for improvement in minitablet packaging and dispensing systems.
Main Methods:
- Comprehensive literature review of available dosing systems (sachets, blisters, electronic dispensers, manual dispensers).
- Simulation of handling and dosing procedures using 2 mm diameter placebo minitablets.
Main Results:
- No current dosing approach fully meets user expectations for minitablets.
- Identified needs include eliminating shaking, adjustable cavity diameters, and enhanced humidity protection.
- Further development is required for optimal minitablet packaging and dispensing.
Conclusions:
- Despite advancements, challenges remain in developing ideal minitablet dosing systems.
- Optimized systems will enhance the convenience, safety, and reliability of individualized therapy, particularly for pediatric and geriatric populations.
Related Concept Videos
01:28Factors Influencing Drug Absorption: Pharmaceutical Parameters
208
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
208
01:23Factors Affecting Dissolution: Particle Size and Effective Surface Area
1.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
1.1K
01:01Dosage Regimen: Fixed Dose
2.0K
Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
2.0K
01:02Noncompartmental Analysis: Mean Transit, Absorption and Dissolution Time
175
When drugs are administered extravascularly, a comprehensive evaluation through noncompartmental analysis becomes imperative. This analytical approach considers various parameters that play a crucial role in understanding the pharmacokinetics of these drugs.
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...
One of the key parameters is the mean transit time (MTT), which refers to the total duration required for drug molecules to transit through the body. MTT is determined by calculating the ratio of the area under the moment curve to the area...
175
01:27Factors Influencing Drug Absorption: Drug Dissolution
760
The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
760
01:24Rational Dosage Regimen: Maintenance Dose and Loading Dose
4.5K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
4.5K