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Published on: May 4, 2020
Bronchopulmonary Dysplasia and Chronic Lung Disease: Stem Cell Therapy
Maria Pierro1, Elena Ciarmoli2, Bernard Thébaud3
1Department of Clinical Sciences and Community Health, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Via della Commenda 12, Milan 20122, Italy; Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, Via Gerolamo Gaslini, 5, Genova 16148, Italy.
Abstract:
Bronchopulmonary dysplasia (BPD), a major complication of premature birth, still lacks safe and effective treatment. Mesenchymal stem cells (MSCs) have been proven to ameliorate critical aspects of the BPD pathogenesis. MSCs seem to exert therapeutic effects through the paracrine secretion of anti-inflammatory, antioxidant, antiapoptotic, trophic, and proangiogenic factors. Although these findings are promising, understanding the mechanism of action of MSCs and MSC manufacturing is still evolving. Several aspects can affect the efficacy of MSC therapy. Further research is required to optimize this potentially game-changing treatment but the translation of regenerative cell therapies for patients has begun.
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