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Microbial Biosensors

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Updated: Mar 29, 2026

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Published on: November 4, 2021

Hydrogel microparticles for biosensing.

Gaelle C Le Goff¹, Rathi L Srinivas², W Adam Hill³

¹Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge 02139, USA ; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.

European Polymer Journal

|November 24, 2015

Summary

This summary is machine-generated.

Hydrogel particles offer a tunable, biocompatible platform for sensitive biosensing. Advanced microfabrication techniques enable multiplexed detection in biological samples, advancing diagnostic capabilities.

Keywords:

biosensor hydrogel microparticle multiplex assay

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Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Hydrogel Nanoparticle Harvesting of Plasma or Urine for Detecting Low Abundance Proteins

Published on: August 7, 2014

Area of Science:

Biomaterials Science
Nanotechnology
Biotechnology

Background:

Hydrogels possess hydrophilic, biocompatible, and tunable properties, making them attractive for biotechnological applications.
Their non-fouling nature and solution-like environment are ideal for biosensing in complex biological samples.
Previous applications include hydrogel coatings and gel dot microarrays for nucleic acid and immunoassays.

Purpose of the Study:

To review key design considerations for hydrogel particles in biosensing.
To explore strategies for material engineering, bioprobe immobilization, and particle fabrication/encoding.
To discuss post-assay processing, decoding methods, and current applications of hydrogel particle arrays.

Main Methods:

Review of microfabrication techniques, including lithography and droplet-based microfluidics, for synthesizing encoded hydrogel particles.
Discussion of methods for tuning hydrogel properties and immobilizing biomolecules.
Analysis of strategies for particle processing and decoding in suspension arrays.

Main Results:

Hydrogel-based suspension arrays can be fabricated with unique spectral or graphical codes for multiplexed sensing.
These arrays demonstrate successful application in sensitive nucleic acid assays and immunoassays.
The review highlights the potential for advanced hydrogel particle design in complex biological sample analysis.

Conclusions:

Hydrogel particles represent a versatile platform for developing advanced biosensing technologies.
Microfabrication techniques enable the creation of sophisticated, multiplexed detection systems.
Further development in hydrogel particle design promises significant advancements in bioassay capabilities.