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Extensive Darier Disease Successfully Treated with Doxycycline Monotherapy
Alicia Sfecci1, Camille Orion1, Laure Darrieux1
1Department of Dermatology, Centre Hospitalier de Saint-Brieuc, Saint-Brieuc, France.
Abstract:
Darier disease (DD) is a rare dominantly inherited genodermatosis characterized by loss of intercellular adhesion (acantholysis) and abnormal keratinization. DD is often difficult to manage. Numerous treatments have reportedly been used for the treatment of DD, with limited success. Systemic retinoids are considered the drug of choice for treating DD. However, their use is limited by potential deleterious side effects. Considering the recently reported efficacy of doxycycline for Hailey-Hailey disease, an inherited acantholytic skin disorder pathogenetically similar to DD, we report the case of a patient with extensive DD who showed a dramatic response to oral doxycycline monotherapy.
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