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Updated: Mar 29, 2026
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
Multifocal BRAF(V600E)-Mutated Melanoma in situ on the Foot
Eimei Iwama1, Taku Fujimura1, Yoshiyuki Kusakari1
1Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Abstract:
Melanoma is an aggressive skin cancer that originates from melanocytes, and about one half of melanoma cases possess a BRAF mutation. Together with PD-L1 expression, the BRAF(V600E) mutation is one of the optimal therapeutic targets for the treatment of melanoma. In this report, we describe a case of multifocal melanoma in situ on the foot, which carried the p.V600E mutation in the BRAF gene. Interestingly, the spotted melanoma lesion is demarcated by normal skin, and in all spotted pigmented lesions, there were no signs of dermal invasion of melanoma cells or spontaneous regression. Our case presented atypical clinical features, which might correlate with the local mutations of BRAF gene and the immunological expression of PD-L1.
Insights
This study reports a rare case of multifocal melanoma in situ with a BRAF(V600E) mutation. Atypical clinical features may link to BRAF mutations and PD-L1 expression in melanoma.
Area of Science:
- Dermatology
- Oncology
- Genetics
Background:
- Melanoma is an aggressive skin cancer originating from melanocytes.
- Approximately 50% of melanoma cases harbor a BRAF mutation.
- BRAF(V600E) mutation and PD-L1 expression are key therapeutic targets in melanoma treatment.
Observation:
- A unique case of multifocal melanoma in situ on the foot is presented.
- The melanoma exhibited the BRAF p.V600E mutation.
- Lesions were well-demarcated by normal skin, with no dermal invasion or spontaneous regression observed.
Findings:
- The case presented atypical clinical features.
- These features may be associated with localized BRAF gene mutations.
- Immunological expression of PD-L1 was also noted.
Implications:
- Understanding atypical melanoma presentations is crucial for diagnosis.
- The interplay between BRAF mutations and PD-L1 expression warrants further investigation.
- This case highlights the complexity of melanoma pathogenesis and potential therapeutic strategies.
