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Models for Predicting Drug Absorption From Oral Lipid-Based Formulations
Linda C Alskär1, Christel A S Bergström1
1Department of Pharmacy, Uppsala University, Uppsala Biomedical Center, P.O Box 580, SE-751 23 Uppsala, Sweden.
Current Molecular Biology Reports
|November 24, 2015
Summary
This review covers in vitro tools for assessing oral lipid-based drug delivery formulations. It highlights strategies to enhance in vitro-in vivo correlations and introduces computational methods for formulation development and mechanistic understanding.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Formulation Development
Background:
- Assessing the oral delivery potential of poorly water-soluble drugs using lipid-based formulations is crucial.
- Current in vitro tools have limitations in predicting in vivo performance.
Approach:
- This review evaluates existing in vitro methodologies for lipid-based formulations.
- It discusses strategies to improve in vitro-in vivo correlations.
- Emerging computational approaches for formulation development are presented.
Key Points:
- In vitro tools are essential for predicting oral drug delivery of lipid-based formulations.
- Improving the correlation between in vitro tests and in vivo outcomes is a key challenge.
- Computational methods offer a promising alternative to traditional laboratory testing.
Conclusions:
- Enhanced in vitro-in vivo correlations are needed for reliable formulation assessment.
- Computational tools can streamline formulation development and deepen mechanistic insights.
- These advancements aim to optimize the oral delivery of poorly soluble drugs.
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