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Effect of Octreotide on Colonic Motility in Pediatric Patients With Chronic Recalcitrant Constipation

Kalyan Ray Parashette1, Shamaila Waseem, Debra Horn

  • 1*Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of New Mexico Children's Hospital, Albuquerque †Division of Pediatric Gastroenterology, Hepatology and Nutrition ‡Department of Anesthesia, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis.

Journal of Pediatric Gastroenterology and Nutrition
|November 24, 2015
PubMed

Insights

Octreotide did not significantly alter colonic motility in pediatric patients with chronic constipation. This study found no change in Motility Index (MI) after octreotide administration in children with recalcitrant constipation.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Motility Research
  • Pharmacological Studies in Children

Background:

  • Chronic constipation and encopresis are common in children, often linked to colonic motility disorders.
  • Investigating novel therapeutic agents for pediatric constipation is crucial due to its impact on quality of life.

Purpose of the Study:

  • To evaluate the effect of octreotide on colonic motility in pediatric patients with recalcitrant chronic constipation/encopresis.
  • To assess potential changes in Motility Index (MI) following octreotide administration in this patient group.

Main Methods:

  • A prospective, open-label, single-center study was conducted.
  • A single subcutaneous dose of octreotide was administered to pediatric patients.
  • Colonic motility was assessed by measuring the Motility Index (MI) before and after octreotide infusion.

Main Results:

  • Thirteen pediatric patients (ages 4.6-16.2 years) were included.
  • No statistically significant changes in colonic Motility Index (MI) were observed at 15, 30, or 45 minutes post-octreotide administration (P > 0.08).
  • Most patients (84%) had normal colonic manometry, while 16% had colonic neuropathy.

Conclusions:

  • Octreotide administration did not result in significant changes in colonic motility in pediatric patients with chronic recalcitrant constipation.
  • These findings suggest octreotide may not be an effective treatment for improving colonic motility in this population.
Abstract

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