Delphi Consensus on Diagnostic Criteria for LUMBAR Syndrome.

Area of Science:

• Pediatric Neurology
• Dermatology
• Genetics

Background:

• LUMBAR syndrome is a complex neurocutaneous disorder.
• It involves segmental infantile hemangiomas and multiple organ system anomalies.
• Lack of standardized diagnostic criteria hinders research and clinical care.

Purpose of the Study:

• To establish consensus-based diagnostic criteria for LUMBAR syndrome.
• To improve the identification and understanding of this rare condition.
• To facilitate standardized research and clinical management.

Main Methods:

• Multidisciplinary expert panel formation.
• Analysis of peer-reviewed literature.
• Electronic-Delphi consensus process with 61 international pediatric specialists.

Main Results:

• High consensus (≥92%) achieved on Delphi statements.
• 98% agreement on the proposed diagnostic criteria.
• Criteria require segmental infantile hemangioma plus one additional anomaly (genitourinary, spinal, bony, anorectal, arterial, or renal).

Conclusions:

• The new criteria will enhance clinical care through improved screening and detection.
• Standardized criteria will enable better phenotypic uniformity for research cohorts.
• These criteria provide a foundation for future prospective studies and management guidelines.