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Decrease in B-Type Natriuretic Peptide Levels and Successful Catheter Ablation for Atrial Fibrillation in Patients

Satoshi Yanagisawa1, Yasuya Inden1, Hiroyuki Kato1

  • 1Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Pacing and Clinical Electrophysiology : PACE
|November 25, 2015
PubMed

Insights

Successful catheter ablation significantly reduced B-type natriuretic peptide (BNP) levels in heart failure patients with atrial fibrillation (AF). This reduction in BNP correlates with improved cardiac function and sustained sinus rhythm.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Management

Background:

  • Limited data exists on B-type natriuretic peptide (BNP) levels following catheter ablation for atrial fibrillation (AF) in heart failure patients.
  • Association between AF elimination and BNP levels in patients with left ventricular systolic dysfunction is not well understood.

Purpose of the Study:

  • To investigate the impact of catheter ablation for AF on BNP levels.
  • To assess the relationship between successful AF ablation and changes in BNP in patients with impaired left ventricular ejection fraction (LVEF).

Main Methods:

  • Radiofrequency catheter ablation for AF was performed in 54 patients with LVEF ≤ 50%.
  • BNP levels were measured at baseline, 3 days, and 1 month post-ablation.
  • Patients were followed for 6 months to assess AF recurrence.

Main Results:

  • BNP levels significantly decreased in patients without AF recurrence (P < 0.001) but not in those with recurrence (P = 0.368).
  • A greater percentage reduction in BNP from baseline to 1 month was observed in the non-recurrence group (56.5%) compared to the recurrence group (-2.4%, P = 0.027).
  • BNP reduction correlated with LVEF improvement (r = 0.486, P < 0.001).

Conclusions:

  • Successful catheter ablation of AF leads to significant reductions in plasma BNP levels in patients with impaired LVEF.
  • Decreased BNP levels may indicate early cardiac function recovery and successful maintenance of sinus rhythm.
Abstract

Keywords:
B-type natriuretic peptideatrial fibrillationcatheter ablationheart failurereverse remodeling

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