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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: Mar 29, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Merkel cell carcinoma: An algorithm for multidisciplinary management and decision-making.

Isabel Prieto1, Teresa Pérez de la Fuente2, Susana Medina3

  • 1Radiation Oncology, Fundación Jiménez Díaz, Avd. Reyes Católicos 2, 28040 Madrid, Spain.

Critical Reviews in Oncology/Hematology
|November 25, 2015
PubMed
Summary

Merkel cell carcinoma (MCC) management requires a multidisciplinary approach. Sentinel node biopsy is crucial for survival prediction in this rare skin cancer, necessitating improved team collaboration and decision-making.

Keywords:
Algorithm for treatmentDecision makingMerkel cell carcinomaMultidisciplinar management

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Oncology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer with rising incidence and poor prognosis.
  • Optimal therapeutic strategies and pathogenesis remain controversial, highlighting a need for improved management protocols.
  • Current treatment approaches often lack clarity, particularly concerning lymph node basin management.

Purpose of the Study:

  • To review scientific evidence on the contributions of various specialists in MCC management.
  • To enhance multidisciplinary decision-making for optimizing patient care.
  • To propose a decision algorithm for the integrated management of MCC.

Main Methods:

  • Systematic review of previously published research on Merkel cell carcinoma.
  • Analysis of the interrelationships between tumor and node management decisions.
  • Evaluation of the role of sentinel node biopsy in predicting patient survival.

Main Results:

  • Sentinel node biopsy is the most consistent predictor of survival in MCC patients.
  • Effective systemic treatments are lacking, leading to frequent distant failures.
  • Multidisciplinary team management is identified as beneficial for patient care.

Conclusions:

  • Multidisciplinary team management significantly improves care for Merkel cell carcinoma patients.
  • A standardized multidisciplinary decision algorithm is proposed for MCC management.
  • Further research and collaboration are needed to address therapeutic uncertainties in MCC.