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Genetic Susceptibility to Cardiac and Digestive Clinical Forms of Chronic Chagas Disease: Involvement of the CCR5

Amanda Priscila de Oliveira1, Cássia Rubia Bernardo1, Ana Vitória da Silveira Camargo1

  • 1Laboratório de Imunogenética, Departamento de Biologia Molecular, Faculdade de Medicina de São José do Rio Preto, Avenida Brigadeiro Faria Lima, 5416, 15090-000, São José do Rio Preto, SP, Brazil.

Plos One
|November 25, 2015
PubMed

Insights

The CCR5 59029 A/G gene polymorphism is linked to Chagas disease susceptibility, but not its cardiac dysfunction. The CCR5Δ32 variant showed no influence on Chagas disease clinical forms.

Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • Chagas disease presents varied clinical forms, including cardiac and digestive manifestations.
  • The genetic factors influencing Chagas disease progression remain incompletely understood.
  • The CCR5 gene plays a role in immune responses and has known polymorphisms.

Purpose of the Study:

  • To investigate the association between CCR5 gene polymorphisms (CCR5Δ32 and CCR5 59029 A/G) and clinical forms of chronic Chagas disease.
  • To determine if these polymorphisms correlate with left ventricular systolic dysfunction severity in chronic Chagas heart disease (CCHD).

Main Methods:

  • Antibodies against T. cruzi were detected using ELISA.
  • CCR5Δ32 and CCR5 59029 A/G polymorphisms were identified via PCR and PCR-RFLP.
  • Genotype frequencies were compared between patient groups and controls using the chi-square test.

Main Results:

  • A higher frequency of the AA genotype for CCR5 59029 A/G was observed in CCHD patients compared to digestive form patients and controls.
  • The AG genotype of CCR5 59029 A/G was more frequent in patients with the digestive form of Chagas disease.
  • Neither CCR5Δ32 nor CCR5 59029 A/G polymorphisms were associated with left ventricular systolic dysfunction severity in CCHD.

Conclusions:

  • The CCR5Δ32 polymorphism does not appear to influence the clinical manifestations of Chagas disease.
  • The CCR5 59029 A/G polymorphism is implicated in susceptibility to different clinical forms of chronic Chagas disease.
  • These CCR5 polymorphisms do not affect the severity of left ventricular systolic dysfunction in patients with CCHD.

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