Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Sir John Cornforth AC CBE FRS: his biosynthetic work.

Rupert Purchase, James R Hanson

    Science Progress
    |November 26, 2015
    PubMed
    Summary

    Sir John Cornforth

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Removal of Toxic Metabolites-Chelation: Manganese Disorders.

    Journal of inherited metabolic disease·2025
    Same author

    Comment on "Trientine Tetrahydrochloride, From Bench to Bedside: A Narrative Review".

    Drugs·2025
    Same author

    Mild Epoxidation of Allylic Alcohols Catalyzed by Titanium(III) Complexes: Selectivity and Mechanism.

    ACS omega·2019
    Same author

    Diterpenoids of terrestrial origin.

    Natural product reports·2019
    Same author

    Imaging of changes in copper trafficking and redistribution in a mouse model of Niemann-Pick C disease using positron emission tomography.

    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2019
    Same author

    Structural and biosynthetic studies on eremophilenols related to the phytoalexin capsidiol, produced by Botrytis cinerea.

    Phytochemistry·2018

    Area of Science:

    • Biochemistry
    • Organic Chemistry
    • Enzymology

    Background:

    • Reviews Sir John Cornforth's seminal contributions to understanding enzyme reaction stereochemistry.
    • Focuses on the biosynthesis of squalene and cholesterol.
    • Examines the stereochemical aspects of chiral methyl group metabolism in acetyl co-enzyme A.

    Discussion:

    • Highlights the importance of stereochemistry in biological pathways.
    • Connects enzymatic mechanisms to the precise spatial arrangement of atoms.
    • Discusses the implications for metabolic processes and molecular recognition.

    Key Insights:

    • Cornforth elucidated the stereochemical outcomes of key biosynthetic steps.
    • Demonstrated the chiral nature of methyl group transfer in acetyl co-enzyme A.
    • Provided foundational insights into enzyme-catalyzed stereoselective reactions.

    Outlook:

    • Cornforth's work continues to influence modern mechanistic enzymology.
    • Underpins research in drug design and understanding metabolic disorders.
    • Emphasizes the critical role of stereochemistry in life sciences.

    Related Experiment Videos