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Trained immunity: a new avenue for tuberculosis vaccine development
1Division of Microbiology and Molecular Medicine, Faculty of Medicine and Health Sciences, Linköping, Sweden.
Journal of Internal Medicine
|November 26, 2015
Summary
Innate immunity, particularly trained immunity, offers new ways to fight tuberculosis (TB). This immune response can remember past infections, improving host defense and potentially aiding vaccine development for TB control.
Area of Science:
- Immunology
- Infectious Diseases
- Tuberculosis Research
Background:
- Adaptive immunity to tuberculosis (TB) is well-studied.
- Innate immunity's crucial role in TB defense is increasingly recognized.
- Pattern recognition receptors highlight innate immunity's specificity.
Purpose of the Study:
- To explore the concept of trained immunity in the context of tuberculosis.
- To discuss the potential of trained immunity for novel TB control strategies.
Main Methods:
- Review of current literature on innate and adaptive immunity in TB.
- Discussion of emerging evidence for innate immune memory.
- Conceptual framework presentation of trained immunity.
Main Results:
- Innate immunity demonstrates specificity and memory, challenging previous notions.
- Trained immunity shows potential for enhanced host defense against TB.
- This concept offers new perspectives beyond traditional adaptive immunity.
Conclusions:
- Trained immunity is a significant factor in host defense against infection.
- The role of innate immunity, including trained immunity, in TB control warrants further investigation.
- Exploring trained immunity may unlock new avenues for TB prevention and treatment.
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