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The Relationship Between High-Sensitivity C-Reactive Protein Levels and Left Ventricular Hypertrophy in Patients With

Ergun Seyfeli1, Bahadir Sarli2, Hayrettin Saglam2

  • 1Department of Cardiology, School of Medicine, Acibadem University, Istanbul, Turkey.

Journal of Clinical Hypertension (Greenwich, Conn.)
|November 26, 2015
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) is elevated in hypertensive patients and linked to left ventricular diastolic dysfunction and concentric hypertrophy. This finding suggests hs-CRP may indicate cardiac changes in hypertension.

Area of Science:

  • Cardiology
  • Biomarkers
  • Hypertension Research

Background:

  • Hypertension is a major risk factor for cardiovascular disease.
  • Left ventricular hypertrophy (LVH) and diastolic dysfunction are common complications of hypertension.
  • High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation.

Purpose of the Study:

  • To investigate the association between hs-CRP levels and the presence of LVH and diastolic dysfunction in newly diagnosed hypertensive patients.
  • To explore the relationship between hs-CRP and different types of LVH (concentric remodeling, concentric hypertrophy, eccentric hypertrophy).

Main Methods:

  • A study included 95 newly diagnosed hypertensive patients and 20 controls.
  • Patients were classified into four groups based on relative wall thickness: normal, concentric remodeling, concentric hypertrophy, and eccentric hypertrophy.
  • Serum hs-CRP levels were measured in all participants.

Main Results:

  • Serum hs-CRP levels were significantly higher in hypertensive patients compared to controls (0.57 mg/dL vs 0.25 mg/dL, P<.001).
  • hs-CRP levels were highest in patients with concentric hypertrophy.
  • Significantly elevated hs-CRP was observed in patients with concentric remodeling (0.61±0.3 mg/dL) and concentric hypertrophy (0.69±0.3 mg/dL) compared to controls.

Conclusions:

  • Serum hs-CRP is significantly associated with left ventricular diastolic function in hypertensive patients.
  • Elevated hs-CRP levels correlate with concentric hypertrophy in individuals with hypertension.

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