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Fucoidans Disrupt Adherence of Helicobacter pylori to AGS Cells In Vitro

Eng-Guan Chua1, Phebe Verbrugghe1, Timothy T Perkins1

  • 1The Marshall Centre for Infectious Diseases Research and Training, School of Pathology and Laboratory Medicine (M502), The University of Western Australia, 35 Stirling Highway, Nedlands, WA 6009, Australia.

Evidence-Based Complementary and Alternative Medicine : Ecam
|November 26, 2015
PubMed

Insights

Fucoidans, derived from marine algae, did not inhibit Helicobacter pylori growth but reduced its adhesion to stomach cells in vitro. Further research is suggested for their clinical use.

Area of Science:

  • Marine natural products
  • Microbiology
  • Cell biology

Background:

  • Fucoidans are complex sulfated polysaccharides from marine algae.
  • Helicobacter pylori is a significant gastric pathogen requiring antibiotic treatment.
  • Investigating natural compounds for anti-H. pylori activity is crucial.

Purpose of the Study:

  • To evaluate the in vitro efficacy of fucoidans against Helicobacter pylori.
  • To determine if fucoidans inhibit H. pylori growth and adhesion to gastric cells.
  • To assess the safety of fucoidans on gastric epithelial cells.

Main Methods:

  • Three fucoidan extracts (Fucus A, Fucus B, Undaria) were tested.
  • Bacterial growth inhibition assays were performed.
  • Adhesion assays using gastric epithelial cells (AGS) were conducted.
  • Cytotoxicity of fucoidans on AGS cells was evaluated.

Main Results:

  • Fucoidans did not inhibit H. pylori growth in culture media.
  • High concentration (1000 µg/mL) fucoidans were toxic to AGS cells.
  • Lower concentration (100 µg/mL) fucoidans significantly reduced H. pylori adhesion to AGS cells.

Conclusions:

  • Fucoidans show potential in reducing H. pylori adhesion to gastric cells.
  • Fucoidans may serve as complementary agents in H. pylori management.
  • Further in vitro and in vivo studies are warranted to explore clinical applications.

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