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[Pharmacokinetics of intravenous anesthetics in aged patients]
Agressologie: Revue Internationale De Physio-Biologie Et De Pharmacologie Appliquees Aux Effets De L'Agression
|January 1, 1989
Abstract:
This paper reviews the pharmacokinetic modifications of anaesthetic intravenous drugs in elderly reported in the literature. With benzodiazepines, the elimination half-life is prolonged and can increase the duration of the sedative effect. With hypnotics, the increase of pharmacological effect (intensity and duration) is due to a decrease of initial volume of distribution and total body clearance. Except morphine, the pharmacokinetic of opioids is slightly changed and can't explain the increase of the pharmacodynamic sensibility.