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Mandibular Tissue Engineering: Past, Present, Future.

Sandra Konopnicki1, Maria J Troulis2

  • 1Research Fellow, Skeletal Biology Research Center, Department of Oral and Maxillofacial Surgery, Massachusetts General Hospital, Boston, MA; and Resident, Department of Oral/Maxillofacial Surgery, Lille University Hospital, Lille, France.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|November 27, 2015
PubMed
Summary
This summary is machine-generated.

Distraction osteogenesis (DO) is an in vivo tissue engineering technique that minimizes invasiveness and donor site morbidity for jaw reconstruction. Future tissue engineering innovations promise further reductions in morbidity and cost, increasing treatment accessibility.

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Oral and Maxillofacial Surgery

Background:

  • Distraction osteogenesis (DO) has evolved significantly since its inception.
  • Minimally invasive jaw reconstruction techniques have increased the need to reduce donor site morbidity.
  • Technological advancements have enabled the development of remotely activated, endoscopic distractors.

Purpose of the Study:

  • To review the historical development and current applications of distraction osteogenesis.
  • To explore the role of tissue engineering in bone reconstruction.
  • To present a future vision for tissue-engineered bone regeneration.

Main Methods:

  • Review of historical literature and clinical experience in distraction osteogenesis.
  • Discussion of advancements in minimally invasive surgical techniques and device development.
  • Exploration of tissue engineering principles applied to bone regeneration.

Main Results:

  • Development of U.S. patented curvilinear automated devices for endoscopic jaw reconstruction.
  • Distraction osteogenesis (DO) offers a less invasive alternative to traditional methods, reducing operative time and eliminating donor sites.
  • Tissue engineering holds potential to further decrease morbidity, reduce costs, and broaden treatment availability.

Conclusions:

  • Distraction osteogenesis represents a significant advancement in bone reconstruction, merging surgical techniques with tissue engineering.
  • Continued innovation in tissue engineering is crucial for enhancing the efficacy and accessibility of regenerative therapies.
  • The future of bone reconstruction lies in further integrating minimally invasive approaches with advanced tissue engineering strategies.