Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aging01:26

Aging

1.0K
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
1.0K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

4.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
4.1K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.4K
Replicative Cell Senescence02:15

Replicative Cell Senescence

3.5K
3.5K
Replicative Cell Senescence02:15

Replicative Cell Senescence

4.6K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.6K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

4.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aging of the adaptive immune system affects the gut microbiome and systemic levels of vitamin B6.

Microbiome·2026
Same author

The need to increase support for healthy ageing and longevity research in the EU by establishing a Coordination and Support Programme on Healthy Ageing and Longevity.

Mechanisms of ageing and development·2026
Same author

A deep learning approach to assess transendothelial cell trafficking performance.

Scientific reports·2026
Same author

Protocol to quantify cell-surface vimentin on senescent human chondrocytes and other cell types via a cell-based ELISA.

STAR protocols·2026
Same author

Overactivation of Cdc42 GTPase Impairs the Cytotoxic Function of NK Cells From Old Individuals Towards Senescent Fibroblasts.

Aging cell·2026
Same author

Elevated levels of Ube2g1 in hematopoietic stem cells lead to segmental aging of the hematopoietic system.

Haematologica·2026

Related Experiment Video

Updated: Mar 29, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.5K

HSC Aging and Senescent Immune Remodeling.

Michael D Denkinger1, Hanna Leins2, Reinhold Schirmbeck3

  • 1Institute for Molecular Medicine, Stem Cells and Aging, Ulm University, Ulm, Germany; aging research center, Ulm University, Ulm, Germany; AGAPLESION Bethesda Clinic, Geriatric Medicine, Ulm University, Ulm, Germany; Geriatric Center Ulm/Alb-Donau, Ulm, Germany.

Trends in Immunology
|November 28, 2015
PubMed
Summary

Immune system aging, known as senescent immune remodeling (SIR), is driven by changes in T and B cells. Hematopoietic stem cell (HSC) aging also contributes, suggesting HSC rejuvenation as a therapeutic strategy.

More Related Videos

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
08:56

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

Published on: July 12, 2022

3.7K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.7K

Related Experiment Videos

Last Updated: Mar 29, 2026

Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

35.5K
Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
08:56

Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells

Published on: July 12, 2022

3.7K
A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence

Published on: August 12, 2018

8.7K

Area of Science:

  • Immunology
  • Gerontology
  • Hematology

Background:

  • Immune system function declines with age, a process termed senescent immune remodeling (SIR).
  • T and B cell aging are key components of SIR.
  • The aging hematopoietic stem cell (HSC) compartment's role in SIR is increasingly recognized.

Purpose of the Study:

  • To review the cellular and molecular mechanisms of SIR.
  • To highlight the contribution of HSC aging to SIR.
  • To discuss potential strategies for mitigating SIR.

Main Methods:

  • Review of current literature on SIR.
  • Analysis of aging-associated changes in immune cells (T and B cells).
  • Examination of HSC aging and differentiation alterations.

Main Results:

  • Aging impacts T and B cell function, contributing to SIR.
  • Aging of HSCs, with altered differentiation, directly drives SIR.
  • Evidence suggests a causal link between HSC aging and immune senescence.

Conclusions:

  • HSC aging is a significant factor in senescent immune remodeling.
  • Strategies targeting HSC rejuvenation may offer therapeutic benefits for SIR.
  • Targeting HSCs presents a novel clinical approach for age-related immune dysfunction.