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Glucocorticoids and Rheumatoid Arthritis.
Joana Fonseca Ferreira1, Alaa Abdelkhalik Ahmed Mohamed2, Paul Emery3
1Rheumatology Unit, Hospitais da Universidade de Coimbra, Centro Hospitalar e Universitário de Coimbra, Praceta Prof. Mota Pinto, 3000-075 Coimbra, Portugal.
Rheumatic Diseases Clinics of North America
|November 28, 2015
Summary
Glucocorticoids (GCs) are effective and affordable rheumatoid arthritis treatments. Research has clarified their benefits, side effects, and how to minimize harm over 70 years.
Area of Science:
- Rheumatology
- Pharmacology
- Immunology
Background:
- Glucocorticoids (GCs) have been used since 1948 for rheumatoid arthritis.
- GCs are widely used due to efficacy, low cost, and symptom relief.
- Extensive research has elucidated GC mechanisms of action and side effects.
Purpose of the Study:
- To review the clinical applications of GCs in rheumatoid arthritis.
- To summarize the known side effects associated with GC therapy.
- To discuss drug interactions involving GCs.
Main Methods:
- Literature review of clinical studies and pharmacological research.
- Analysis of mechanisms of therapeutic action and adverse effects.
- Examination of strategies to mitigate GC side effects.
Main Results:
- GCs demonstrate significant efficacy in managing rheumatoid arthritis symptoms.
- Understanding of GC mechanisms has grown substantially over seven decades.
- Methods to minimize side effects and manage drug interactions have been developed.
Conclusions:
- Glucocorticoids remain a cornerstone therapy for rheumatoid arthritis.
- Continued research focuses on optimizing GC use and minimizing adverse events.
- This review provides a comprehensive overview for clinicians.
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