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Basal Ganglia Iron in Patients with Multiple Sclerosis Measured with 7T Quantitative Susceptibility Mapping
P Schmalbrock1, R S Prakash2, B Schirda2
1From the Departments of Radiology (P.S., G.K.Y., M. Russell, M.V.K.) petra.schmalbrock@osumc.edu.
AJNR. American Journal of Neuroradiology
|November 28, 2015
Summary
Quantitative susceptibility mapping and R2 show promise as complementary indicators for basal ganglia changes in multiple sclerosis (MS). Increased quantitative susceptibility mapping is linked to poorer inhibitory control in MS patients.
Area of Science:
- Neuroimaging
- Neurology
- Biophysics
Background:
- T2 hypointensity in basal ganglia correlates with MS progression and cognitive decline.
- Basal ganglia dysfunction impacts inhibitory control in multiple sclerosis.
Purpose of the Study:
- Compare T2WI, R2, R2*, and quantitative susceptibility mapping (QSM) in MS basal ganglia.
- Investigate associations between MR imaging metrics, clinical scores, and cognitive inhibitory control.
Main Methods:
- 29 MS patients underwent neuropsychological tests (Flanker, Stroop) and 7T MRI.
- Acquired 3D gradient-echo and spin-echo EPI sequences.
- Calculated QSM using Wiener filter; R2/R2* via log-linear regression; normalized T2WI to CSF.
Main Results:
- QSM and T2/T2*WI showed spatial variation within basal ganglia structures.
- QSM metrics correlated with Flanker task performance but not Stroop.
- Putamen QSM and R2, and caudate R2, correlated with Expanded Disability Status Scale.
Conclusions:
- QSM and R2 are potentially complementary for detecting basal ganglia tissue changes in MS.
- Increased QSM aligns with impaired inhibitory control in MS patients.
