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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
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Mutations01:35

Mutations

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Mar 29, 2026

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Skin Cancer.

Miguel A Linares1, Alan Zakaria2, Parminder Nizran3

  • 1Primary Care Sports Medicine Fellow, Henry Ford Hospital, 2799 W Grand Boulevard, Detroit, MI 48208, USA.

Primary Care
|November 28, 2015
PubMed
Summary
This summary is machine-generated.

Skin cancer is the most common malignancy globally, including melanoma and nonmelanoma types like basal cell and squamous cell carcinoma. Primary prevention focuses on avoiding sun exposure and tanning beds due to risks like fair skin and ultraviolet B radiation.

Keywords:
Basal cell carcinomaDermoscopyExcision marginHistopathologicMelanomaMelanonychiaSquamous cell carcinoma

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Area of Science:

  • Oncology
  • Dermatology
  • Public Health

Background:

  • Skin cancer represents a significant global health burden, comprising the majority of all malignancies.
  • Malignant skin neoplasms are broadly categorized into melanoma and nonmelanoma types.
  • Nonmelanoma skin cancers encompass basal cell carcinoma and squamous cell carcinoma.

Purpose of the Study:

  • To outline the primary classifications of skin cancer.
  • To identify key risk factors associated with nonmelanoma skin cancer.
  • To describe primary prevention strategies for skin cancer.

Main Methods:

  • Literature review of epidemiological data on skin cancer.
  • Analysis of risk factors including skin type and ultraviolet radiation exposure.
  • Summary of established primary prevention guidelines.

Main Results:

  • Nonmelanoma skin cancer, including basal cell carcinoma and squamous cell carcinoma, is highly prevalent.
  • Fair skin phenotype and cumulative exposure to ultraviolet B (UVB) radiation are identified as critical risk factors.
  • Effective primary prevention strategies involve minimizing sun exposure and avoiding artificial tanning sources.

Conclusions:

  • Understanding skin cancer subtypes and their risk factors is crucial for public health initiatives.
  • Primary prevention through behavioral modification, such as sun avoidance, is paramount in reducing skin cancer incidence.
  • Public awareness campaigns emphasizing sun safety are essential for global skin cancer control.