Jove
Visualize
Contact Us

Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

5.8K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
5.8K
Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

2.7K
2.7K
Microtubules in Signaling01:22

Microtubules in Signaling

2.3K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
2.3K
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

5.0K
Microtubules are thick hollow cylindrical proteins that help form the cytoskeleton. Microtubules have varied roles in the cell. These filaments help form cellular appendages like cilia and flagella, which are responsible for locomotion. The cilia arise from basal bodies, separated from the main body by a membrane-like structure forming the transition zone. This zone is the gate for the entry of lipids and proteins, creating a unique composition of lipids and proteins in the ciliary membrane and...
5.0K
Microtubules in Cell Motility01:24

Microtubules in Cell Motility

1.7K
1.7K
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

11.6K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SCM-1/SCAMP Maintains Microdomain Boundaries and Cargo Sorting within the Endosomal System.

bioRxiv : the preprint server for biology·2026
Same author

Joubert syndrome gene <i>fam149b1</i> homolog, <i>xbx-4</i> , is required for multiple sensory behaviors.

microPublication biology·2026
Same author

A <i>C. elegans</i> model for functional analysis of ADPKD variants in cilia, extracellular vesicles, and sensory signaling.

bioRxiv : the preprint server for biology·2026
Same author

The extracellular matrix gene <i>mec-9</i> regulates <i>C. elegans</i> sensory cilia.

bioRxiv : the preprint server for biology·2026
Same author

Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes in C. elegans.

Nature communications·2025
Same author

SID-2 is a conserved extracellular vesicle protein that is not associated with environmental RNAi in parasitic nematodes.

Open biology·2024
Same journal

Addendum: In situ architecture of the human prohibitin complex.

Nature cell biology·2026
Same journal

Evolutionarily conserved short linear motifs drive actin filament binding.

Nature cell biology·2026
Same journal

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration.

Nature cell biology·2026
Same journal

Author Correction: Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance.

Nature cell biology·2026
Same journal

An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.

Nature cell biology·2026
Same journal

Primate neurons with special signalling logic.

Nature cell biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 29, 2026

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
07:53

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium

Published on: January 16, 2018

8.8K

A motor relay on ciliary tracks.

Robert O'Hagan1, Maureen M Barr1

  • 1Rutgers University, Human Genetics Institute and Department of Genetics, 145 Bevier Road, Piscataway, New Jersey 08854, USA.

Nature Cell Biology
|November 28, 2015
PubMed
Summary
This summary is machine-generated.

Kinesin-2 motors, heterotrimeric kinesin-II and homodimeric OSM-3, exhibit distinct running styles in cilia. Their coordinated

More Related Videos

Artificial Intelligence Approaches to Assessing Primary Cilia
08:58

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

4.3K
Simple Detection of Primary Cilia by Immunofluorescence
08:07

Simple Detection of Primary Cilia by Immunofluorescence

Published on: May 15, 2020

12.1K

Related Experiment Videos

Last Updated: Mar 29, 2026

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
07:53

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium

Published on: January 16, 2018

8.8K
Artificial Intelligence Approaches to Assessing Primary Cilia
08:58

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

4.3K
Simple Detection of Primary Cilia by Immunofluorescence
08:07

Simple Detection of Primary Cilia by Immunofluorescence

Published on: May 15, 2020

12.1K

Area of Science:

  • Cell Biology
  • Molecular Motors
  • Cilia Biology

Background:

  • Cilia are crucial for cellular functions.
  • Kinesin motors play vital roles in intracellular transport.
  • Understanding kinesin-2 dynamics in cilia is essential.

Purpose of the Study:

  • To investigate the transport dynamics of kinesin-2 motors in cilia.
  • To differentiate the roles of heterotrimeric kinesin-II and homodimeric OSM-3.
  • To elucidate the coordination mechanism between these motors.

Main Methods:

  • In vivo two-colour imaging
  • Fourier-filtered kymography
  • Computational simulations

Main Results:

  • Heterotrimeric kinesin-II acts as an 'obstacle-course runner'.
  • Homodimeric OSM-3 (KIF17) functions as a 'long-distance runner'.
  • A 'baton handoff' mechanism between kinesin-2 motors was identified on microtubules.

Conclusions:

  • Kinesin-2 motors display specialized transport behaviors in cilia.
  • The coordinated action of kinesin-2 motors ensures efficient cargo transport.
  • This study provides high-resolution insights into ciliary kinesin-2 dynamics.