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Updated: Mar 29, 2026

Application of High-speed Super-resolution SPEED Microscopy in Live Primary Cilium
Published on: January 16, 2018
A motor relay on ciliary tracks
Robert O'Hagan1, Maureen M Barr1
1Rutgers University, Human Genetics Institute and Department of Genetics, 145 Bevier Road, Piscataway, New Jersey 08854, USA.
Abstract:
A powerful combination of two-colour imaging in vivo, Fourier-filtered kymography and simulations provides a high-resolution view of kinesin-2 transport dynamics in cilia. This study reveals heterotrimeric kinesin-II as an 'obstacle-course runner' and homodimeric OSM-3 (KIF17) as a 'long-distance runner', and elucidates the 'baton handoff' between these two kinesin-2 motors on the microtubule track.
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