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Lung function in allogeneic bone marrow transplantation recipients.

R Rodríguez-Roisin1, J Roca, A Grañena

  • 1Dept. de Medicina, Facultat de Medicina, Universitat de Barcelona, Spain.

The European Respiratory Journal
|April 1, 1989
PubMed
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Pulmonary function complications, including airway hyperreactivity and ventilatory defects, are common after bone marrow transplantation (BMT). These lung function changes are typically transient and mild to moderate in severity.

Area of Science:

  • Pulmonology
  • Hematology
  • Transplantation Medicine

Background:

  • Bone marrow transplantation (BMT) is a critical treatment for hematologic malignancies and aplastic anemia.
  • Pulmonary complications post-BMT can significantly impact patient outcomes.
  • Pre-existing respiratory status and underlying conditions may influence post-transplant pulmonary function.

Purpose of the Study:

  • To investigate the incidence and nature of pulmonary function complications following BMT.
  • To assess changes in lung function over a one-year period post-BMT.
  • To compare pulmonary outcomes between patients with leukemia and aplastic anemia undergoing BMT.

Main Methods:

  • Sequential assessment of 25 patients (17 leukemia, 8 aplastic anemia) over one year.

Related Experiment Videos

  • Pre-BMT evaluation included respiratory symptoms, chest X-ray, and routine lung function tests.
  • Post-BMT assessments included diffusing capacity for carbon monoxide (DLCO), static lung volumes, and bronchial hyperresponsiveness testing.

    • Main Results:

    • Pre-BMT, 5 patients showed airway hyperreactivity; aplastic anemia patients had lower DLCO, linked to lower hemoglobin.
    • Post-BMT, transient mild to moderate reductions in DLCO and static lung volumes were observed.
    • Fourteen patients developed ventilatory defects, 10 with bronchial hyperresponsiveness; leukemia patients had lower post-BMT DLCO than aplastic anemia patients.

    Conclusions:

    • Pulmonary function complications, including ventilatory defects and bronchial hyperresponsiveness, are frequent after BMT.
    • Lung function abnormalities post-BMT are generally transient and mild to moderate.
    • Careful monitoring of pulmonary function is warranted in patients undergoing BMT.