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Updated: Mar 29, 2026

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Automated, High-Throughput Detection of Bacterial Adherence to Host Cells
Published on: September 17, 2021
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Switching first contact: photocontrol of E. coli adhesion to human cells
L Möckl1, A Müller2, C Bräuchle1
1Department of Physical Chemistry, Ludwig Maximilian University of Munich, Butenandtstr. 11, D-81377 Munich, Germany.
Abstract:
We have shown previously that carbohydrate-specific bacterial adhesion to a non-physiological surface can be photocontrolled by reversible E/Z isomerisation using azobenzene-functionalised sugars. Here, this approach is applied to the surface of human cells. We show not only that bacterial adhesion to the azobenzene glycoside-modified cell surface is higher in the E than in the Z state, but add data about the specific modulation of the effect.

