Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Forces Acting on Chromosomes02:11

Forces Acting on Chromosomes

2.0K
2.0K
Forces Acting on Chromosomes02:11

Forces Acting on Chromosomes

4.1K
During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis. 
Microtubules and motor proteins exert two types of forces on...
4.1K
Temperature Dependent Deformation01:12

Temperature Dependent Deformation

615
In a nonhomogeneous rod made up of steel and brass, restrained at both ends and subjected to a temperature change, several steps are involved in calculating the stress and compressive load. Due to the problem's static indeterminacy, one end support is disconnected, allowing the rod to experience the temperature change freely. Next, an unknown force is applied at the free end, triggering deformations in the rod's steel and brass portions. These deformations are then calculated and added...
615
Deformation of Member under Multiple Loadings01:11

Deformation of Member under Multiple Loadings

610
When a rod is made of different materials or has various cross-sections, it must be divided into parts that meet the necessary conditions for determining the deformation. These parts are each characterized by their internal force, cross-sectional area, length, and modulus of elasticity. These parameters are then used to compute the deformation of the entire rod.
In the case of a member with a variable cross-section, the strain is not constant but depends on the position. The deformation of an...
610
DNA Topoisomerases02:02

DNA Topoisomerases

37.5K
Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types. ...
37.5K
DNA Helicases00:55

DNA Helicases

24.9K
DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
24.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

C-DNA may facilitate homologous DNA pairing.

Trends in genetics : TIG·2023
Same author

Modulation of C-to-T mutation by recombination-independent pairing of closely positioned DNA repeats.

Biophysical journal·2021
Same author

Recombination-independent recognition of DNA homology for meiotic silencing in <i>Neurospora crassa</i>.

Proceedings of the National Academy of Sciences of the United States of America·2021
Same author

Direct Homologous dsDNA-dsDNA Pairing: How, Where, and Why?

Journal of molecular biology·2019
Same author

Partition of Repeat-Induced Point Mutations Reveals Structural Aspects of Homologous DNA-DNA Pairing.

Biophysical journal·2018
Same author

Weak nanoscale chaos and anomalous relaxation in DNA.

Physical review. E·2017

Related Experiment Video

Updated: Mar 29, 2026

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers
08:48

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Published on: October 13, 2011

13.6K

Modeling DNA Dynamics under Steady Deforming Forces and Torques.

Alexey K Mazur1

  • 1CNRS UPR9080, Institut de Biologie Physico-Chimique, 13, rue Pierre et Marie Curie, Paris 75005, France.

Journal of Chemical Theory and Computation
|November 28, 2015
PubMed
Summary

A new algorithm models DNA dynamics under torque and stretching. This enables studying DNA

Area of Science:

  • Biophysics
  • Computational Biology
  • Molecular Dynamics

Background:

  • Understanding DNA mechanics is crucial for molecular biology.
  • Simulating DNA's response to external forces requires accurate computational models.

Purpose of the Study:

  • To develop and validate an algorithm for modeling atom-level DNA dynamics.
  • To investigate DNA's elastic responses to steady external torques and stretching loads.

Main Methods:

  • Developed a novel algorithm for simulating DNA dynamics.
  • Employed Brownian dynamics simulations of discrete wormlike chain models.
  • Conducted 100-ns all-atom Molecular Dynamics (MD) simulations with explicit water and ions.

Main Results:

More Related Videos

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K
DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

7.3K

Related Experiment Videos

Last Updated: Mar 29, 2026

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers
08:48

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Published on: October 13, 2011

13.6K
Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion
09:17

Structure-Based Simulation and Sampling of Transcription Factor Protein Movements along DNA from Atomic-Scale Stepping to Coarse-Grained Diffusion

Published on: March 1, 2022

3.6K
DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers
08:00

DNA Nanotubes as a Versatile Tool to Study Semiflexible Polymers

Published on: October 25, 2017

7.3K
  • Validated the algorithm's ability to accurately model DNA elastic responses.
  • Demonstrated the algorithm's effectiveness under low, near-physiological forces and torques.
  • Confirmed no undesirable side effects during simulations.

Conclusions:

  • The developed algorithm enables precise modeling of DNA atom-level dynamics.
  • This tool facilitates the study of DNA mechanics under biologically relevant conditions.
  • The findings open avenues for further research into DNA-protein interactions and drug design.