Multiple primary synchronous malignant tumors
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Updated: Mar 29, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
Alberto Testori1, Ugo Cioffi2, Matilde De Simone3
1Department of General and Thoracic Surgery, Humanitas Research Hospital, via Manzoni 56 Rozzano, 20089, Milan, Italy. alberto.testori@humanitas.it.
Background:
Patients with primary multiple malignancies are progressively increasing due to prolonged survival of cancer patients and to the advances in diagnostic techniques and therapeutic options.
Case Presentation:
Here we present a 66 year-old caucasian patient with four synchronous primary malignant tumors affecting the lung, oropharynx, large bowel and prostate gland, respectively, treated with multidisciplinary approach.
Conclusions:
The increased incidence of multiple malignant tumors is a real challenge to the clinician and clinical attention should be made to avoid a misdiagnosis. In addition an early diagnosis is essential to achieve a radical treatment. We believe that the treatment modality should be carefully made and tailored on the individual patient suffering from this disease.
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