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Related Experiment Videos

Tubuloreticular structures and cylindrical confronting cisternae: a review.

J Y Luu1, D Bockus, F Remington

  • 1Department of Pathology, Virginia Mason Medical Center, Seattle, WA.

Human Pathology
|July 1, 1989
PubMed
Summary
This summary is machine-generated.

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Tubuloreticular structures (TRS) and cylindrical confronting cisternae (CCC) are unique cell structures linked to autoimmune diseases and viral infections, particularly AIDS. Interferons alpha and beta, but not gamma, are implicated in their in vivo induction.

Area of Science:

  • Cell Biology
  • Immunology
  • Virology

Background:

  • Tubuloreticular structures (TRS) and cylindrical confronting cisternae (CCC) are unique subcellular formations originating from rough endoplasmic reticulum membranes.
  • These structures are frequently observed in endothelial cells and lymphocytes of patients with autoimmune diseases, viral infections, and notably, acquired immunodeficiency syndrome (AIDS).
  • The precise inducers of TRS and CCC in vivo remain undetermined, though clinical and experimental data suggest a correlation with elevated alpha- and beta-interferon levels, excluding gamma-interferon.

Purpose of the Study:

  • To investigate the inducers and pathogenesis of tubuloreticular structures (TRS) and cylindrical confronting cisternae (CCC).
  • To elucidate the clinical significance and potential role of TRS and CCC in human diseases.
  • To utilize in vitro investigations to clarify the nature and importance of these subcellular structures.

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Main Methods:

  • In vitro investigations using lymphoblastoid cell lines.
  • Analysis of cell types including lymphoblastoid cell lines, healthy donor lymphocytes, and endothelial cells.
  • Induction studies using alpha- and beta-interferon.

Main Results:

  • Both TRS and CCC can be induced in vitro by alpha- and beta-interferon in certain lymphoblastoid cell lines.
  • In healthy donor lymphocytes and endothelial cells, only TRS, not CCC, are induced by these interferons.
  • The study highlights the utility of the lymphoblastoid cell system for isolating TRS and CCC.

Conclusions:

  • Alpha- and beta-interferon are confirmed inducers of TRS and CCC in specific cell lines in vitro.
  • Differential induction of TRS and CCC in various cell types suggests distinct regulatory mechanisms.
  • Further isolation and study of TRS and CCC using lymphoblastoid cell systems are crucial for understanding their role in human diseases.